Product Information

Storage

0.5 mg/ml of antibody in, PBS, pH 7.4, with 50% Glycerol. Shipped and store at 4°C for 1-2 weeks. store at -20°C for long term.

Specificity / Sensitivity

Lamin B1 (D9V6H) Rabbit mAb recognizes endogenous levels of total lamin B1 protein. This antibody recognizes the 45 kDa lamin B1 carboxy terminal cleavage product produced during apoptosis.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys415 of human lamin B1 protein.

Background

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions, such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamins have been subdivided into types A and B. Type-A lamins consist of lamin A and C, which arise from alternative splicing of the lamin A gene LMNA. Lamin A and C are cleaved by caspases into large (41-50 kDa) and small (28 kDa) fragments, which can be used as markers for apoptosis (4,5). Type-B lamins consist of lamin B1 and B2, encoded by separate genes (6-8). Lamin B1 is also cleaved by caspases during apoptosis (9). Research studies have shown that duplication of the lamin B1 gene LMNB1 is correlated with pathogenesis of the neurological disorder adult-onset leukodystrophy

包装清单

保存条件：

LaminB1兔多抗-20℃保存，五年有效。快速封闭及抗体稀释液室温保存，两年有效。

注意事项：

1， 如果本抗体用于WB,IF,ICC等实验，请注意回收使用过的回收抗体，回收的抗体通常可重复使用3-8次，回收后的稀释抗体-20℃或4℃保存。

2， 所提供的快速封闭及抗体稀释液也可用于ELISA，IF,IHC,ICC等适当用途。

3， 本产品仅限于专业人员的科学研究用，不得用于临床诊断和治疗，不得用于食品或药品，不得存放于普通住宅内。

4， 为了您的安全和健康，请穿实验服并戴一次性手套操作。